This research examines methods of responding to doubts from Ayatollah Khamenei’s perspective. In today’s world, doubts are considered a serious alternative to military warfare and strike like poisoned arrows at the body of believers’ beliefs, gradually leading to a reduction in the effectiveness of them. This article analyzes the methods used in responding by a scholar who, due to his responsibilities, has always been at the forefront of responding to doubt-creators and whose capabilities are well-known. The author describes his integrated approach to responding, which involves tackling the root of the doubt with a clear understanding of the audience, accounting for contextual factors such as time and place as well as intelligent prevention and prediction. Additionally, he emphasizes the use of emerging media and attractive approaches appropriate to the audience’s taste in conveying materials and responding to doubts. Additionally, meticulous planning and mobilization of organizational and non-organizational capacities are crucial elements of his approach. This research, conducted through descriptive-analytical methods and based on his statements and related books, opens a new window for those working in the field of responding to doubts and provides materials so that they don’t merely suffice with responding but also use other useful factors.